Dendritic cells transduced with TIPE-2 recombinant adenovirus induces T cells suppression

Abstract Introduction TIPE-2 has been identified as a negative regulator of both innate and adaptive immunity is involved in several inflammatory diseases. However, the role immune suppression dendritic cells (DCs) transduced with not well studied. Methods In this study, DCs were recombinant adenovirus, then cocultured allogeneic CD4+ or CD8 + T cells. The proliferation, cytokine production activation marker levels cell detected. Results data demonstrated that attenuated after treated DCs. Conclusions These results suggested are capable inducing suppression, which provide promising way for therapeutical strategies transplantation autoimmune